1wzy: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1wzy.jpg|left|200px]]
+{{Seed}}
+[[Image:1wzy.png|left|200px]]
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 {{STRUCTURE_1wzy|  PDB=1wzy  |  SCENE=  }}
-'''Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative'''
+===Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative===
-==Overview==
+<!--
-A series of pyrazolopyridazine compounds were briefly investigated as ERK2 inhibitors. The crystal structure of ERK2 complexed with an allyl derivative was determined. The compound induces structural change including movement of the glycine-rich loop and peptide flip between Met108-Glu109. As a result, the newly formed subsite can recognize small hydrophobic substituents but not hydrophilic ones.
+The line below this paragraph, {{ABSTRACT_PUBMED_16242327}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16242327 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16242327}}
 ==About this Structure==
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 [[Category: Inhibitor]]
 [[Category: Kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:21:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:40:44 2008''