2cgp: Difference between revisions

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-[[Image:2cgp.gif|left|200px]]
+{{Seed}}
+[[Image:2cgp.png|left|200px]]
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 {{STRUCTURE_2cgp|  PDB=2cgp  |  SCENE=  }}
-'''CATABOLITE GENE ACTIVATOR PROTEIN/DNA COMPLEX, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE'''
+===CATABOLITE GENE ACTIVATOR PROTEIN/DNA COMPLEX, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE===
-==Overview==
+<!--
-The 2.2 A resolution crystal structure of the Escherichia coli catabolite gene activator protein (CAP) complexed with cAMP and a 46-bp DNA fragment reveals a second cAMP molecule bound to each protein monomer. The second cAMP is in the syn conformation and is located on the DNA binding domain interacting with the helix-turn-helix, a beta-hairpin from the regulatory domain and the DNA (via water molecules). The presence of this second cAMP site resolves the apparent discrepancy between the NMR and x-ray data on the conformation of cAMP, and explains the cAMP concentration-dependent behaviors of the protein. In addition, this site's close proximity to mutations affecting transcriptional activation and its water-mediated interactions with a DNA recognition residue (E181) and DNA raise the possibility that this site has biological relevance.
+The line below this paragraph, {{ABSTRACT_PUBMED_9096308}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9096308 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9096308}}
 ==About this Structure==
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 [[Category: Camp-binding]]
 [[Category: Dna-binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 22:06:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:40:02 2008''