2i1r: Difference between revisions

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{{STRUCTURE_2i1r|  PDB=2i1r  |  SCENE=  }}  
{{STRUCTURE_2i1r|  PDB=2i1r  |  SCENE=  }}  


'''Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure'''
===Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure===




==Overview==
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Structure-activity relationships (SAR) of 1 against HCV NS5B polymerase were described. SAR explorations and further structure-based design led to the identifications of 2 and 3 as novel HCV NS5B inhibitors. X-ray structure of 3 in complex with NS5B polymerase was obtained at a resolution of 2.2A, and confirmed the design.
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{{ABSTRACT_PUBMED_17049849}}


==About this Structure==
==About this Structure==
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[[Category: Rdrp]]
[[Category: Rdrp]]
[[Category: Viral rna-directed rna polymerase]]
[[Category: Viral rna-directed rna polymerase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:58:16 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:36:43 2008''

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