2z3q: Difference between revisions

Revision as of 23:35, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2z3q.png

Template:STRUCTURE 2z3q

Crystal structure of the IL-15/IL-15Ra complexCrystal structure of the IL-15/IL-15Ra complex

Template:ABSTRACT PUBMED 17643103

About this StructureAbout this Structure

2Z3Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans., Chirifu M, Hayashi C, Nakamura T, Toma S, Shuto T, Kai H, Yamagata Y, Davis SJ, Ikemizu S, Nat Immunol. 2007 Sep;8(9):1001-7. Epub 2007 Jul 22. PMID:17643103

Page seeded by OCA on Sun Jul 27 23:35:41 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2z3q.gif|left|200px]]
+{{Seed}}
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 {{STRUCTURE_2z3q|  PDB=2z3q  |  SCENE=  }}
-'''Crystal structure of the IL-15/IL-15Ra complex'''
+===Crystal structure of the IL-15/IL-15Ra complex===
-==Overview==
+<!--
-Interleukin 15 (IL-15) and IL-2, which promote the survival of memory CD8(+) T cells and regulatory T cells, respectively, bind receptor complexes that share beta- and gamma-signaling subunits. Receptor specificity is provided by unique, nonsignaling alpha-subunits. Whereas IL-2 receptor-alpha (IL-2Ralpha) is expressed together in cis with the beta- and gamma-subunits on T cells and B cells, IL-15Ralpha is expressed in trans on antigen-presenting cells. Here we present a 1.85-A crystal structure of the human IL-15-IL-15Ralpha complex. The structure provides insight into the molecular basis of the specificity of cytokine recognition and emphasizes the importance of water in generating this very high-affinity complex. Despite very low IL-15-IL-2 sequence homology and distinct receptor architecture, the topologies of the IL-15-IL-15Ralpha and IL-2-IL-2Ralpha complexes are very similar. Our data raise the possibility that IL-2, like IL-15, might be capable of being presented in trans in the context of its unique receptor alpha-chain.
+The line below this paragraph, {{ABSTRACT_PUBMED_17643103}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17643103 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17643103}}
 ==About this Structure==
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 [[Category: Cytokine/cytokine receptor complex]]
 [[Category: Protein-protein complex]]
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+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:35:41 2008''