1qdn: Difference between revisions

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{{STRUCTURE_1qdn|  PDB=1qdn  |  SCENE=  }}  
{{STRUCTURE_1qdn|  PDB=1qdn  |  SCENE=  }}  


'''AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)'''
===AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)===




==Overview==
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The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) disassembles complexes of membrane-bound proteins known as SNAREs, an activity essential for vesicular trafficking. The amino-terminal domain of NSF (NSF-N) is required for the interaction of NSF with the SNARE complex through the adaptor protein alpha-SNAP. The crystal structure of NSF-N reveals two subdomains linked by a single stretch of polypeptide. A polar interface between the two subdomains indicates that they can move with respect to one another during the catalytic cycle of NSF. Structure-based sequence alignments indicate that in addition to NSF orthologues, the p97 family of ATPases contain an amino-terminal domain of similar structure.
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==About this Structure==
==About this Structure==
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[[Category: Double-psi beta barrel alpha/beta barrel]]
[[Category: Double-psi beta barrel alpha/beta barrel]]
[[Category: Vesicular-fusion protein]]
[[Category: Vesicular-fusion protein]]
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