2ouc: Difference between revisions

Revision as of 23:27, 27 July 2008

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File:2ouc.png

Template:STRUCTURE 2ouc

Crystal structure of the MAP kinase binding domain of MKP5Crystal structure of the MAP kinase binding domain of MKP5

Template:ABSTRACT PUBMED 17400920

About this StructureAbout this Structure

2OUC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5., Tao X, Tong L, Protein Sci. 2007 May;16(5):880-6. Epub 2007 Mar 30. PMID:17400920

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OCA

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-'''Crystal structure of the MAP kinase binding domain of MKP5'''
+===Crystal structure of the MAP kinase binding domain of MKP5===
-==Overview==
+<!--
-MAP kinase phosphatases (MKPs) have crucial roles in regulating the signaling activity of MAP kinases and are potential targets for drug discovery against human diseases. These enzymes contain a catalytic domain (CD) as well as a binding domain (BD) that help recognize the target MAP kinase. We report here the crystal structures at up to 2.2 A resolution of the BD and CD of human MKP5 and compare them to the known structures from other MKPs. Dramatic structural differences are observed between the BD of MKP5 and that of MKP3 determined previously by NMR. In particular, the cluster of positively charged residues that is important for MAP kinase binding is located in completely different positions in the two structures, with a distance of 25 A between them. Moreover, this cluster is alpha-helical in MKP5, while it forms a loop followed by a beta-strand in MKP3. These large structural differences could be associated with the distinct substrate preferences of these phosphatases, but further studies are needed to confirm this. The CD of MKP5 is observed in an active conformation, and two loops in the active site have backbone shifts of up to 5 A relative to the inactive CDs from other MKPs.
+The line below this paragraph, {{ABSTRACT_PUBMED_17400920}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_17400920}}
 ==About this Structure==
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 [[Category: Hydrolase]]
 [[Category: Rhodanese fold]]
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