1owf: Difference between revisions

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-[[Image:1owf.gif|left|200px]]
+{{Seed}}
+[[Image:1owf.png|left|200px]]
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 {{STRUCTURE_1owf|  PDB=1owf  |  SCENE=  }}
-'''Crystal structure of a mutant IHF (BetaE44A) complexed with the native H' Site'''
+===Crystal structure of a mutant IHF (BetaE44A) complexed with the native H' Site===
-==Overview==
+<!--
-Integration host factor (IHF) is a DNA-bending protein that recognizes its cognate sites through indirect readout. Previous studies have shown that binding of wild-type (WT)-IHF is disrupted by a T to A mutation at the center position of a conserved TTR motif in its binding site, and that substitution of betaGlu44 with Ala prevented IHF from discriminating between A and T at this position. We have determined the crystal structures and relative binding affinities for all combinations of WT-IHF and IHF-betaGlu44Ala bound to the WT and mutant DNAs. Comparison of these structures reveals that DNA twist plays a major role in DNA recognition by IHF, and that this geometric parameter is dependent on the dinucleotide step and not on the bound IHF variant.
+The line below this paragraph, {{ABSTRACT_PUBMED_12842466}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12842466 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12842466}}
 ==About this Structure==
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 [[Category: Minor groove]]
 [[Category: Protein-dna recognition]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:21:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:25:16 2008''