2fx6: Difference between revisions

Revision as of 23:06, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2fx6.png

Template:STRUCTURE 2fx6

bovine trypsin complexed with 2-aminobenzamidazolebovine trypsin complexed with 2-aminobenzamidazole

Template:ABSTRACT PUBMED 16681368

About this StructureAbout this Structure

2FX6 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

Structure-guided design of peptide-based tryptase inhibitors., McGrath ME, Sprengeler PA, Hirschbein B, Somoza JR, Lehoux I, Janc JW, Gjerstad E, Graupe M, Estiarte A, Venkataramani C, Liu Y, Yee R, Ho JD, Green MJ, Lee CS, Liu L, Tai V, Spencer J, Sperandio D, Katz BA, Biochemistry. 2006 May 16;45(19):5964-73. PMID:16681368

Page seeded by OCA on Sun Jul 27 23:06:35 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''bovine trypsin complexed with 2-aminobenzamidazole'''
+===bovine trypsin complexed with 2-aminobenzamidazole===
-==Overview==
+<!--
-Improved peptide-based inhibitors of human beta tryptase were discovered using information gleaned from tripeptide library screening and structure-guided design methods, including fragment screening. Our efforts sought to improve this class of inhibitors by replacing the traditional Lys or Arg P1 element. The optimized compounds display low nanomolar potency against the mast cell target and several hundred-fold selectivity with respect to serine protease off targets. Thus, replacement of Lys/Arg at P1 in a peptide-like scaffold does not need to be accompanied by a loss in target affinity.
+The line below this paragraph, {{ABSTRACT_PUBMED_16681368}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16681368 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16681368}}
 ==About this Structure==
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 [[Category: S1 site]]
 [[Category: Serine protease]]
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