1ppg: Difference between revisions

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-[[Image:1ppg.gif|left|200px]]
+{{Seed}}
+[[Image:1ppg.png|left|200px]]
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 {{STRUCTURE_1ppg|  PDB=1ppg  |  SCENE=  }}
-'''THE REFINED 2.3 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN LEUKOCYTE ELASTASE IN A COMPLEX WITH A VALINE CHLOROMETHYL KETONE INHIBITOR'''
+===THE REFINED 2.3 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN LEUKOCYTE ELASTASE IN A COMPLEX WITH A VALINE CHLOROMETHYL KETONE INHIBITOR===
-==Overview==
+<!--
-The stoichiometric complex formed between human leukocyte elastase and a synthetic MeO-Suc-Ala-Ala-Pro-Val chloromethyl ketone inhibitor was co-crystallized and its X-ray structure determined, using Patterson search methods. Its structure has been crystallographically refined to a final R value of 0.145 (8.0 and 2.3 A). The enzyme structure is very similar to that recently observed in a complex formed with the ovomucoid third domain from turkey [(1986) EMBO J. 5,2453-2458]. The rms deviation of all alpha-carbon atoms is 0.32 A. The peptidic inhibitor is bound in a similar overall conformation as the ovomucoid binding segment. Covalent bonds are formed between Val-P1 of the inhibitor and His-57 NE2 and Ser-195 OG of the enzyme. The carbonyl carbon is tetrahedrally deformed to a hemiketal. The valine side chain is arranged in the S1 pocket in the g-conformation.
+The line below this paragraph, {{ABSTRACT_PUBMED_3391280}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 3391280 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_3391280}}
 ==About this Structure==
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 [[Category: Bode, W.]]
 [[Category: Wei, A-Z.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:20:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:49:16 2008''