2iui: Difference between revisions

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-[[Image:2iui.gif|left|200px]]
+{{Seed}}
+[[Image:2iui.png|left|200px]]
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 {{STRUCTURE_2iui|  PDB=2iui  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH PDGFR PHOSPHOTYROSYL PEPTIDE'''
+===CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH PDGFR PHOSPHOTYROSYL PEPTIDE===
-==Overview==
+<!--
-Crystal structures of the amino-terminal SH2 domain of the p85alpha subunit of phosphatidylinositol (PI) 3-kinase, alone and in complex with phosphopeptides bearing pTyr-Met/Val-Xaa-Met motifs, show that phosphopeptides bind in the two-pronged manner seen in high-affinity Lck and Src SH2 complexes, with conserved interactions between the domain and the peptide segment from phosphotyrosine to Met+3. Peptide binding requires the rearrangement of a tyrosyl side chain in the BG loop to create the hydrophobic Met+3 binding pocket. The structures suggest a mechanism for the biological specificity exhibited by PI 3-kinase in its interactions with phosphoprotein partners.
+The line below this paragraph, {{ABSTRACT_PUBMED_8599763}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8599763 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8599763}}
 ==About this Structure==
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 [[Category: Transferase]]
 [[Category: Ubl conjugation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:53:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:24:07 2008''