2pop: Difference between revisions

Revision as of 21:33, 27 July 2008

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File:2pop.png

Template:STRUCTURE 2pop

The Crystal Structure of TAB1 and BIR1 complexThe Crystal Structure of TAB1 and BIR1 complex

Template:ABSTRACT PUBMED 17560374

About this StructureAbout this Structure

2POP is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization., Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H, Mol Cell. 2007 Jun 8;26(5):689-702. PMID:17560374

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OCA

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-'''The Crystal Structure of TAB1 and BIR1 complex'''
+===The Crystal Structure of TAB1 and BIR1 complex===
-==Overview==
+<!--
-In addition to caspase inhibition, X-linked inhibitor of apoptosis (XIAP) induces NF-kappaB and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here we show that the BIR1 domain of XIAP, which has no previously ascribed function, directly interacts with TAB1 to induce NF-kappaB activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-kappaB pathway. We report the crystal structures of BIR1, TAB1, and the BIR1/TAB1 complex. The BIR1/TAB1 structure reveals a striking butterfly-shaped dimer and the detailed interaction between BIR1 and TAB1. Structure-based mutagenesis and knockdown of TAB1 show unambiguously that the BIR1/TAB1 interaction is crucial for XIAP-induced TAK1 and NF-kappaB activation. We show that although not interacting with BIR1, Smac, the antagonist for caspase inhibition by XIAP, also inhibits the XIAP/TAB1 interaction. Disruption of BIR1 dimerization abolishes XIAP-mediated NF-kappaB activation, implicating a proximity-induced mechanism for TAK1 activation.
+The line below this paragraph, {{ABSTRACT_PUBMED_17560374}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17560374 is the PubMed ID number.
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 ==About this Structure==
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 [[Category: Pp2c-like domain]]
 [[Category: Zinc finger]]
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