2ih3: Difference between revisions

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-[[Image:2ih3.gif|left|200px]]
+{{Seed}}
+[[Image:2ih3.png|left|200px]]
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 {{STRUCTURE_2ih3|  PDB=2ih3  |  SCENE=  }}
-'''Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation'''
+===Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation===
-==Overview==
+<!--
-Potassium channels are K+-selective protein pores in cell membrane. The selectivity filter is the functional unit that allows K+ channels to distinguish potassium (K+) and sodium (Na+) ions. The filter's structure depends on whether K+ or Na+ ions are bound inside it. We synthesized a K+ channel containing the d-enantiomer of alanine in place of a conserved glycine and found by x-ray crystallography that its filter maintains the K+ (conductive) structure in the presence of Na+ and very low concentrations of K+. This channel conducts Na+ in the absence of K+ but not in the presence of K+. These findings demonstrate that the ability of the channel to adapt its structure differently to K+ and Na+ is a fundamental aspect of ion selectivity, as is the ability of multiple K+ ions to compete effectively with Na+ for the conductive filter.
+The line below this paragraph, {{ABSTRACT_PUBMED_17095703}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17095703 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17095703}}
 ==About this Structure==
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 [[Category: Valiyaveetil, F I.]]
 [[Category: Ion channel d-amino acid semi-synthetic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:29:45 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:29:35 2008''