2dw1: Difference between revisions

No edit summary
No edit summary
Line 1: Line 1:
[[Image:2dw1.jpg|left|200px]]
{{Seed}}
[[Image:2dw1.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2dw1|  PDB=2dw1  |  SCENE=  }}  
{{STRUCTURE_2dw1|  PDB=2dw1  |  SCENE=  }}  


'''Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal)'''
===Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal)===




==Overview==
<!--
Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.
The line below this paragraph, {{ABSTRACT_PUBMED_17485084}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17485084 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17485084}}


==About this Structure==
==About this Structure==
Line 20: Line 24:
==Reference==
==Reference==
Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17485084 17485084]
Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17485084 17485084]
Crystallization and preliminary X-ray crystallographic analysis of two vascular apoptosis-inducing proteins (VAPs) from Crotalus atrox venom., Igarashi T, Oishi Y, Araki S, Mori H, Takeda S, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):688-91. Epub 2006 Jun 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16820695 16820695]
Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold., Takeda S, Igarashi T, Mori H, Araki S, EMBO J. 2006 Jun 7;25(11):2388-96. Epub 2006 May 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16688218 16688218]
cDNA cloning and some additional peptide characterization of a single-chain vascular apoptosis-inducing protein, VAP2., Masuda S, Maeda H, Miao JY, Hayashi H, Araki S, Endothelium. 2007 Mar-Apr;14(2):89-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17497365 17497365]
Two vascular apoptosis-inducing proteins from snake venom are members of the metalloprotease/disintegrin family., Masuda S, Hayashi H, Araki S, Eur J Biochem. 1998 Apr 1;253(1):36-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9578458 9578458]
[[Category: Crotalus atrox]]
[[Category: Crotalus atrox]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 28: Line 40:
[[Category: Metalloproteinase]]
[[Category: Metalloproteinase]]
[[Category: Svmp]]
[[Category: Svmp]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 01:29:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:14:12 2008''

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA