379d: Difference between revisions

Revision as of 20:56, 27 July 2008

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File:379d.png

Template:STRUCTURE 379d

THE STRUCTURAL BASIS OF HAMMERHEAD RIBOZYME SELF-CLEAVAGETHE STRUCTURAL BASIS OF HAMMERHEAD RIBOZYME SELF-CLEAVAGE

Template:ABSTRACT PUBMED 9506521

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

The structural basis of hammerhead ribozyme self-cleavage., Murray JB, Terwey DP, Maloney L, Karpeisky A, Usman N, Beigelman L, Scott WG, Cell. 1998 Mar 6;92(5):665-73. PMID:9506521

Page seeded by OCA on Sun Jul 27 20:55:59 2008

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OCA

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-'''THE STRUCTURAL BASIS OF HAMMERHEAD RIBOZYME SELF-CLEAVAGE'''
+===THE STRUCTURAL BASIS OF HAMMERHEAD RIBOZYME SELF-CLEAVAGE===
-==Overview==
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-We have captured an 8.7 A conformational change that takes place in the cleavage site of the hammerhead ribozyme during self-cleavage, using X-ray crystallography combined with physical and chemical trapping techniques. This rearrangement brings the hammerhead ribozyme from the ground state into a conformation that is poised to form the transition state geometry required for hammerhead RNA self-cleavage. Use of a 5'-C-methylated ribose adjacent to the cleavage site permits this ordinarily transient conformational change to be kinetically trapped and observed crystallographically after initiating the hammerhead ribozyme reaction in the crystal. Cleavage of the corresponding unmodified hammerhead ribozyme in the crystal under otherwise identical conditions is faster than in solution, indicating that we have indeed trapped a catalytically relevant intermediate form of this RNA enzyme.
+The line below this paragraph, {{ABSTRACT_PUBMED_9506521}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_9506521}}
 ==About this Structure==
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 [[Category: Loop]]
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