2p15: Difference between revisions

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-[[Image:2p15.gif|left|200px]]
+{{Seed}}
+[[Image:2p15.png|left|200px]]
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 {{STRUCTURE_2p15|  PDB=2p15  |  SCENE=  }}
-'''Crystal structure of the ER alpha ligand binding domain with the agonist ortho-trifluoromethylphenylvinyl estradiol'''
+===Crystal structure of the ER alpha ligand binding domain with the agonist ortho-trifluoromethylphenylvinyl estradiol===
-==Overview==
+<!--
-The steroid hormone receptors are characterized by binding to relatively rigid, inflexible endogenous steroid ligands. Other members of the nuclear receptor superfamily bind to conformationally flexible lipids and show a corresponding degree of elasticity in the ligand-binding pocket. Here, we report the X-ray crystal structure of the oestrogen receptor alpha (ERalpha) bound to an oestradiol derivative with a prosthetic group, ortho- trifluoromethlyphenylvinyl, which binds in a novel extended pocket in the ligand-binding domain. Unlike ER antagonists with bulky side groups, this derivative is enclosed in the ligand-binding pocket, and acts as a potent agonist. This work shows that steroid hormone receptors can interact with a wider array of pharmacophores than previously thought through structural plasticity in the ligand-binding pocket.
+The line below this paragraph, {{ABSTRACT_PUBMED_17468738}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17468738 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17468738}}
 ==About this Structure==
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 [[Category: Ligand binding domain]]
 [[Category: Nulear receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:07:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:35:43 2008''