2gzd: Difference between revisions

Revision as of 20:34, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2gzd.png

Template:STRUCTURE 2gzd

Crystal Structure of Rab11 in Complex with Rab11-FIP2Crystal Structure of Rab11 in Complex with Rab11-FIP2

Template:ABSTRACT PUBMED 16905101

About this StructureAbout this Structure

2GZD is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of rab11 in complex with rab11 family interacting protein 2., Jagoe WN, Lindsay AJ, Read RJ, McCoy AJ, McCaffrey MW, Khan AR, Structure. 2006 Aug;14(8):1273-83. PMID:16905101

Page seeded by OCA on Sun Jul 27 20:34:51 2008

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-[[Image:2gzd.gif|left|200px]]
+{{Seed}}
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 {{STRUCTURE_2gzd|  PDB=2gzd  |  SCENE=  }}
-'''Crystal Structure of Rab11 in Complex with Rab11-FIP2'''
+===Crystal Structure of Rab11 in Complex with Rab11-FIP2===
-==Overview==
+<!--
-The small GTPase Rab11 regulates the recycling of endosomes to the plasma membrane via interactions with the Rab11 family of interacting proteins (FIPs). FIPs contain a highly conserved Rab binding domain (RBD) at their C termini whose structure is unknown. Here, we have determined the crystal structure of the RBD of FIP2 in complex with Rab11(GTP) by single wavelength anomalous diffraction methods. The overall structure is a heterotetramer with dyad symmetry, arranged as a Rab11-(FIP2)2-Rab11 complex. FIP2 forms a central alpha-helical coiled coil, with both helices contributing to the Rab11 binding patch on equivalent and opposite sides of the homodimer. Switch 1 of Rab11 is embedded between the two helices, while switch 2 remains flexible and is peripherally associated with the effector. The complex reveals the structural basis for Rab11 recognition by FIPs and suggests the molecular mechanisms underlying endocytic recycling pathways.
+The line below this paragraph, {{ABSTRACT_PUBMED_16905101}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16905101 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16905101}}
 ==About this Structure==
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 [[Category: A-helical coiled coil]]
 [[Category: G protein fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:40:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:34:51 2008''