2gj4: Difference between revisions

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[[Image:2gj4.gif|left|200px]]
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{{STRUCTURE_2gj4|  PDB=2gj4  |  SCENE=  }}  
{{STRUCTURE_2gj4|  PDB=2gj4  |  SCENE=  }}  


'''Structure of rabbit muscle glycogen phosphorylase in complex with ligand'''
===Structure of rabbit muscle glycogen phosphorylase in complex with ligand===




==Overview==
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Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described. Representative compounds have been shown to bind at the dimer interface site of the rabbit muscle enzyme by X-ray crystallography.
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{{ABSTRACT_PUBMED_16945526}}


==About this Structure==
==About this Structure==
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[[Category: Tucker, J.]]
[[Category: Tucker, J.]]
[[Category: Glycogen phosphorylase]]
[[Category: Glycogen phosphorylase]]
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Revision as of 20:32, 27 July 2008

File:2gj4.png

Template:STRUCTURE 2gj4

Structure of rabbit muscle glycogen phosphorylase in complex with ligandStructure of rabbit muscle glycogen phosphorylase in complex with ligand

Template:ABSTRACT PUBMED 16945526

About this StructureAbout this Structure

2GJ4 is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

ReferenceReference

Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies., Whittamore PR, Addie MS, Bennett SN, Birch AM, Butters M, Godfrey L, Kenny PW, Morley AD, Murray PM, Oikonomakos NG, Otterbein LR, Pannifer AD, Parker JS, Readman K, Siedlecki PS, Schofield P, Stocker A, Taylor MJ, Townsend LA, Whalley DP, Whitehouse J, Bioorg Med Chem Lett. 2006 Nov 1;16(21):5567-71. Epub 2006 Aug 30. PMID:16945526

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