1w9b: Difference between revisions

Revision as of 19:33, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1w9b.png

Template:STRUCTURE 1w9b

S. ALBA MYROSINASE IN COMPLEX WITH CARBA-GLUCOTROPAEOLINS. ALBA MYROSINASE IN COMPLEX WITH CARBA-GLUCOTROPAEOLIN

Template:ABSTRACT PUBMED 15889170

About this StructureAbout this Structure

1W9B is a Single protein structure of sequence from Sinapis alba. Full crystallographic information is available from OCA.

ReferenceReference

The glucosinolate-myrosinase system. New insights into enzyme-substrate interactions by use of simplified inhibitors., Bourderioux A, Lefoix M, Gueyrard D, Tatibouet A, Cottaz S, Arzt S, Burmeister WP, Rollin P, Org Biomol Chem. 2005 May 21;3(10):1872-9. Epub 2005 Apr 14. PMID:15889170

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OCA

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-'''S. ALBA MYROSINASE IN COMPLEX WITH CARBA-GLUCOTROPAEOLIN'''
+===S. ALBA MYROSINASE IN COMPLEX WITH CARBA-GLUCOTROPAEOLIN===
-==Overview==
+<!--
-Myrosinase, a thioglucoside glucohydrolase, is the only enzyme able to hydrolyse glucosinolates, a unique family of molecules bearing an anomeric O-sulfated thiohydroximate function. Non-hydrolysable myrosinase inhibitors have been devised and studied for their biological interaction. Diverse modifications of the O-sulfate moiety did not result in a significant inhibitory effect, whereas replacing the D-glucopyrano residue by its carba-analogue allowed inhibition to take place. X-Ray experiments carried out after soaking allowed for the first time inclusion of a non-hydrolysable inhibitor inside the enzymatic pocket. Structural tuning of the aglycon part in its pocket is being used as a guide for the development of simplified and more potent inhibitors.
+The line below this paragraph, {{ABSTRACT_PUBMED_15889170}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_15889170}}
 ==About this Structure==
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 [[Category: Thioglycosidase]]
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