2i39: Difference between revisions

Revision as of 19:25, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2i39.png

Template:STRUCTURE 2i39

Crystal structure of Vaccinia virus N1L proteinCrystal structure of Vaccinia virus N1L protein

Template:ABSTRACT PUBMED 17123957

About this StructureAbout this Structure

2I39 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

ReferenceReference

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein., Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC, Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:17123957

Page seeded by OCA on Sun Jul 27 19:25:26 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2i39.gif|left|200px]]
+{{Seed}}
+[[Image:2i39.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2i39|  PDB=2i39  |  SCENE=  }}
-'''Crystal structure of Vaccinia virus N1L protein'''
+===Crystal structure of Vaccinia virus N1L protein===
-==Overview==
+<!--
-Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.
+The line below this paragraph, {{ABSTRACT_PUBMED_17123957}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17123957 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17123957}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Stec, B.]]
 [[Category: All alpha]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:01:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:25:26 2008''