2viu: Difference between revisions

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[[Image:2viu.gif|left|200px]]
{{Seed}}
[[Image:2viu.png|left|200px]]


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{{STRUCTURE_2viu|  PDB=2viu  |  SCENE=  }}  
{{STRUCTURE_2viu|  PDB=2viu  |  SCENE=  }}  


'''INFLUENZA VIRUS HEMAGGLUTININ'''
===INFLUENZA VIRUS HEMAGGLUTININ===




==Overview==
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The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.
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{{ABSTRACT_PUBMED_9461077}}


==About this Structure==
==About this Structure==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Hemagglutinin]]
[[Category: Hemagglutinin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:53:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:14:37 2008''

Revision as of 19:14, 27 July 2008

File:2viu.png

Template:STRUCTURE 2viu

INFLUENZA VIRUS HEMAGGLUTINININFLUENZA VIRUS HEMAGGLUTININ

Template:ABSTRACT PUBMED 9461077

About this StructureAbout this Structure

2VIU is a Single protein structure of sequence from Unidentified influenza virus. Full crystallographic information is available from OCA.

ReferenceReference

Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077

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