2d3d: Difference between revisions

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 {{STRUCTURE_2d3d|  PDB=2d3d  |  SCENE=  }}
-'''crystal structure of the RNA binding SAM domain of saccharomyces cerevisiae Vts1'''
+===crystal structure of the RNA binding SAM domain of saccharomyces cerevisiae Vts1===
-==Overview==
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-The SAM domain of the Saccharomyces cerevisiae post-transcriptional regulator Vts1 has a high affinity towards RNA hairpins containing a CUGGC pentaloop. We present the 1.6 Angstroms X-ray crystal structure of the Vts1 SAM domain in its unliganded state, and the NMR solution structure of this domain in its RNA-bound state. Both structures reveal a canonical five helix SAM domain flanked by additional secondary structural elements at the N and C termini. The two structures are essentially identical, implying that no major structural rearrangements occur upon RNA binding. Amide chemical shift changes map the RNA-binding site to a shallow, basic patch at the junction of helix alpha5 and the loop connecting helices alpha1 and alpha2.
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+{{ABSTRACT_PUBMED_16375924}}
 ==About this Structure==
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 ==Reference==
 The NMR and X-ray structures of the Saccharomyces cerevisiae Vts1 SAM domain define a surface for the recognition of RNA hairpins., Aviv T, Amborski AN, Zhao XS, Kwan JJ, Johnson PE, Sicheri F, Donaldson LW, J Mol Biol. 2006 Feb 17;356(2):274-9. Epub 2005 Dec 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16375924 16375924]
+The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators., Aviv T, Lin Z, Lau S, Rendl LM, Sicheri F, Smibert CA, Nat Struct Biol. 2003 Aug;10(8):614-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12858164 12858164]
 [[Category: Saccharomyces cerevisiae]]
 [[Category: Single protein]]
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 [[Category: Sam domain]]
 [[Category: Sre hairpin binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:37:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:02:56 2008''