1oe6: Difference between revisions

Revision as of 18:41, 27 July 2008

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File:1oe6.png

Template:STRUCTURE 1oe6

XENOPUS SMUG1, AN ANTI-MUTATOR URACIL-DNA GLYCOSYLASEXENOPUS SMUG1, AN ANTI-MUTATOR URACIL-DNA GLYCOSYLASE

Template:ABSTRACT PUBMED 12820976

About this StructureAbout this Structure

1OE6 is a Protein complex structure of sequences from Xenopus laevis. Full crystallographic information is available from OCA.

ReferenceReference

Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1., Wibley JE, Waters TR, Haushalter K, Verdine GL, Pearl LH, Mol Cell. 2003 Jun;11(6):1647-59. PMID:12820976

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OCA

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-[[Image:1oe6.gif|left|200px]]
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-'''XENOPUS SMUG1, AN ANTI-MUTATOR URACIL-DNA GLYCOSYLASE'''
+===XENOPUS SMUG1, AN ANTI-MUTATOR URACIL-DNA GLYCOSYLASE===
-==Overview==
+<!--
-Cytosine deamination is a major promutagenic process, generating G:U mismatches that can cause transition mutations if not repaired. Uracil is also introduced into DNA via nonmutagenic incorporation of dUTP during replication. In bacteria, uracil is excised by uracil-DNA glycosylases (UDG) related to E. coli UNG, and UNG homologs are found in mammals and viruses. Ung knockout mice display no increase in mutation frequency due to a second UDG activity, SMUG1, which is specialized for antimutational uracil excision in mammalian cells. Remarkably, SMUG1 also excises the oxidation-damage product 5-hydroxymethyluracil (HmU), but like UNG is inactive against thymine (5-methyluracil), a chemical substructure of HmU. We have solved the crystal structure of SMUG1 complexed with DNA and base-excision products. This structure indicates a more invasive interaction with dsDNA than observed with other UDGs and reveals an elegant water displacement/replacement mechanism that allows SMUG1 to exclude thymine from its active site while accepting HmU.
+The line below this paragraph, {{ABSTRACT_PUBMED_12820976}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12820976 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12820976}}
 ==About this Structure==
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 [[Category: Single stranded]]
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