1onq: Difference between revisions

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{{STRUCTURE_1onq|  PDB=1onq  |  SCENE=  }}  
{{STRUCTURE_1onq|  PDB=1onq  |  SCENE=  }}  


'''Crystal Structure of CD1a in Complex with a Sulfatide'''
===Crystal Structure of CD1a in Complex with a Sulfatide===




==Overview==
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CD1 antigens bind a variety of self and foreign lipid and glycolipid antigens for presentation to CD1-restricted T cell receptors (TCRs). Here we report the crystal structure of human CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. The lipid adopts an S-shaped conformation, with the sphingosine chain completely buried in the A' pocket and the fatty acid chain emerging from the interface of the A' pocket into the more exposed F' pocket. The headgroup is anchored in the A'-F' junction and protrudes into the F' pocket for TCR recognition. Because the A' pocket is narrow with a fixed terminus, it can act as a molecular 'ruler' to select alkyl chains of a particular length.
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{{ABSTRACT_PUBMED_12833155}}


==Disease==
==Disease==
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[[Category: Beta sheet platform]]
[[Category: Beta sheet platform]]
[[Category: Protein-glycolipid complex]]
[[Category: Protein-glycolipid complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:04:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:04:34 2008''

Revision as of 17:04, 27 July 2008

File:1onq.png

Template:STRUCTURE 1onq

Crystal Structure of CD1a in Complex with a SulfatideCrystal Structure of CD1a in Complex with a Sulfatide

Template:ABSTRACT PUBMED 12833155

DiseaseDisease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this StructureAbout this Structure

1ONQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A., Zajonc DM, Elsliger MA, Teyton L, Wilson IA, Nat Immunol. 2003 Aug;4(8):808-15. Epub 2003 Jun 29. PMID:12833155

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