2i9t: Difference between revisions

Revision as of 17:04, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2i9t.png

Template:STRUCTURE 2i9t

Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoterStructure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter

Template:ABSTRACT PUBMED 12005436

About this StructureAbout this Structure

2I9T is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter., Escalante CR, Shen L, Thanos D, Aggarwal AK, Structure. 2002 Mar;10(3):383-91. PMID:12005436

Page seeded by OCA on Sun Jul 27 17:04:20 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter'''
+===Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter===
-==Overview==
+<!--
-Upon viral infection, NF-kappaB translocates to the nucleus and activates the IFN-beta gene by binding to the PRDII element. Strikingly, NF-kappaB loses its ability to activate the IFN-beta gene when the PRDII element is substituted by closely related sites. We report here the crystal structure of NF-kappaB p50/p65 heterodimer bound to the PRDII element from the IFN-beta promoter. The structure reveals an unexpected alteration in configuration, in which the p50 specificity domain moves by as much as approximately 9 A when compared to NF-kappaB heterodimer bound to the immunoglobulin kappaB site (Ig-kappaB) while maintaining the same base-specific contacts with the DNA. Taken together, the structure offers new insights into the allosteric effects of closely related DNA sites on the configuration of NF-kappaB and its transcriptional selectivity.
+The line below this paragraph, {{ABSTRACT_PUBMED_12005436}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_12005436}}
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 [[Category: Thanos, D.]]
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