2f8u: Difference between revisions

Revision as of 16:59, 27 July 2008

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File:2f8u.png

Template:STRUCTURE 2f8u

Solution structure of G-quadruplex formed in the human Bcl-2 promoterSolution structure of G-quadruplex formed in the human Bcl-2 promoter

Template:ABSTRACT PUBMED 16998187

About this StructureAbout this Structure

Full experimental information is available from OCA.

ReferenceReference

NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region., Dai J, Chen D, Jones RA, Hurley LH, Yang D, Nucleic Acids Res. 2006;34(18):5133-44. Epub 2006 Sep 22. PMID:16998187

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OCA

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-'''Solution structure of G-quadruplex formed in the human Bcl-2 promoter'''
+===Solution structure of G-quadruplex formed in the human Bcl-2 promoter===
-==Overview==
+<!--
-BCL2 protein functions as an inhibitor of cell apoptosis and has been found to be aberrantly expressed in a wide range of human diseases. A highly GC-rich region upstream of the P1 promoter plays an important role in the transcriptional regulation of BCL2. Here we report the NMR solution structure of the major intramolecular G-quadruplex formed on the G-rich strand of this region in K+ solution. This well-defined mixed parallel/antiparallel-stranded G-quadruplex structure contains three G-tetrads of mixed G-arrangements, which are connected with two lateral loops and one side loop, and four grooves of different widths. The three loops interact with the core G-tetrads in a specific way that defines and stabilizes the overall G-quadruplex structure. The loop conformations are in accord with the experimental mutation and footprinting data. The first 3-nt loop adopts a lateral loop conformation and appears to determine the overall folding of the BCL2 G-quadruplex. The third 1-nt double-chain-reversal loop defines another example of a stable parallel-stranded structural motif using the G3NG3 sequence. Significantly, the distinct major BCL2 promoter G-quadruplex structure suggests that it can be specifically involved in gene modulation and can be an attractive target for pathway-specific drug design.
+The line below this paragraph, {{ABSTRACT_PUBMED_16998187}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16998187 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_16998187}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8U OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8U OCA].
 ==Reference==
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 [[Category: G-quadruplex]]
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