2fa1: Difference between revisions

Revision as of 16:55, 27 July 2008

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File:2fa1.png

Template:STRUCTURE 2fa1

Crystal structure of PhnF C-terminal domainCrystal structure of PhnF C-terminal domain

Template:ABSTRACT PUBMED 16672238

About this StructureAbout this Structure

2FA1 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Structural characterization of GntR/HutC family signaling domain., Gorelik M, Lunin VV, Skarina T, Savchenko A, Protein Sci. 2006 Jun;15(6):1506-11. Epub 2006 May 2. PMID:16672238

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal structure of PhnF C-terminal domain'''
+===Crystal structure of PhnF C-terminal domain===
-==Overview==
+<!--
-The crystal structure of Escherichia coli PhnF C-terminal domain (C-PhnF) was solved at 1.7 A resolution by the single wavelength anomalous dispersion (SAD) method. The PhnF protein belongs to the HutC subfamily of the large GntR transcriptional regulator family. Members of this family share similar N-terminal DNA-binding domains, but are divided into four subfamilies according to their heterogenic C-terminal domains, which are involved in effector binding and oligomerization. The C-PhnF structure provides for the first time the scaffold of this domain for the HutC subfamily, which covers about 31% of GntR-like regulators. The structure represents a mixture of alpha-helices and beta-strands, with a six-stranded antiparallel beta-sheet at the core. C-PhnF monomers form a dimer by establishing interdomain eight-strand beta-sheets that include core antiparallel and N-terminal two-strand parallel beta-sheets from each monomer. C-PhnF shares strong structural similarity with the chorismate lyase fold, which features a buried active site locked behind two helix-turn-helix loops. The structural comparison of the C-PhnF and UbiC proteins allows us to propose that a similar site in the PhnF structure is adapted for effector binding.
+The line below this paragraph, {{ABSTRACT_PUBMED_16672238}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_16672238}}
 ==About this Structure==
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 [[Category: Regulator]]
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