2qf7: Difference between revisions

Revision as of 16:47, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2qf7.png

Template:STRUCTURE 2qf7

Crystal structure of a complete multifunctional pyruvate carboxylase from Rhizobium etliCrystal structure of a complete multifunctional pyruvate carboxylase from Rhizobium etli

Template:ABSTRACT PUBMED 17717183

About this StructureAbout this Structure

2QF7 is a Single protein structure of sequence from Rhizobium etli. Full crystallographic information is available from OCA.

ReferenceReference

Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme., St Maurice M, Reinhardt L, Surinya KH, Attwood PV, Wallace JC, Cleland WW, Rayment I, Science. 2007 Aug 24;317(5841):1076-9. PMID:17717183

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal structure of a complete multifunctional pyruvate carboxylase from Rhizobium etli'''
+===Crystal structure of a complete multifunctional pyruvate carboxylase from Rhizobium etli===
-==Overview==
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-Biotin-dependent multifunctional enzymes carry out metabolically important carboxyl group transfer reactions and are potential targets for the treatment of obesity and type 2 diabetes. These enzymes use a tethered biotin cofactor to carry an activated carboxyl group between distantly spaced active sites. The mechanism of this transfer has remained poorly understood. Here we report the complete structure of pyruvate carboxylase at 2.0 angstroms resolution, which shows its domain arrangement. The structure, when combined with mutagenic analysis, shows that intermediate transfer occurs between active sites on separate polypeptide chains. In addition, domain rearrangements associated with activator binding decrease the distance between active-site pairs, providing a mechanism for allosteric activation. This description provides insight into the function of biotin-dependent enzymes and presents a new paradigm for multifunctional enzyme catalysis.
+The line below this paragraph, {{ABSTRACT_PUBMED_17717183}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_17717183}}
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 [[Category: Multi-domain]]
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