2c39: Difference between revisions

Revision as of 15:36, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2c39.png

Template:STRUCTURE 2c39

RNASE PH CORE OF THE ARCHAEAL EXOSOME IN COMPLEX WITH ADPRNASE PH CORE OF THE ARCHAEAL EXOSOME IN COMPLEX WITH ADP

Template:ABSTRACT PUBMED 16285928

About this StructureAbout this Structure

2C39 is a Protein complex structure of sequences from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of 3' end RNA recognition and exoribonucleolytic cleavage by an exosome RNase PH core., Lorentzen E, Conti E, Mol Cell. 2005 Nov 11;20(3):473-81. PMID:16285928

Page seeded by OCA on Sun Jul 27 15:36:50 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2c39.gif|left|200px]]
+{{Seed}}
+[[Image:2c39.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2c39|  PDB=2c39  |  SCENE=  }}
-'''RNASE PH CORE OF THE ARCHAEAL EXOSOME IN COMPLEX WITH ADP'''
+===RNASE PH CORE OF THE ARCHAEAL EXOSOME IN COMPLEX WITH ADP===
-==Overview==
+<!--
-The exosome is a macromolecular complex that plays fundamental roles in the biogenesis and turnover of a large number of RNA species. Here we report the crystal structures of the Rrp41-Rrp42 core complex of the S. solfataricus exosome bound to short single-stranded RNAs and to ADP. The RNA binding cleft recognizes four nucleotides in a sequence-unspecific manner, mainly by electrostatic interactions with the phosphate groups. Interactions at the 2' hydroxyls of the sugars provide specificity for RNA over DNA. The structures show both the bound substrate and the cleaved product of the reaction, suggesting a catalytic mechanism for the 3'-5' phosphorolytic activity of the exosome.
+The line below this paragraph, {{ABSTRACT_PUBMED_16285928}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16285928 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16285928}}
 ==About this Structure==
@@ Line 35: / Line 39: @@
 [[Category: Rrp41]]
 [[Category: Rrp42]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:10:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:36:50 2008''