2oah: Difference between revisions

Revision as of 15:24, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2oah.png

Template:STRUCTURE 2oah

Crystal Structure of Human Beta Secretase Complexed with inhibitorCrystal Structure of Human Beta Secretase Complexed with inhibitor

Template:ABSTRACT PUBMED 17257835

About this StructureAbout this Structure

2OAH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation., Stauffer SR, Stanton MG, Gregro AR, Steinbeiser MA, Shaffer JR, Nantermet PG, Barrow JC, Rittle KE, Collusi D, Espeseth AS, Lai MT, Pietrak BL, Holloway MK, McGaughey GB, Munshi SK, Hochman JH, Simon AJ, Selnick HG, Graham SL, Vacca JP, Bioorg Med Chem Lett. 2007 Mar 15;17(6):1788-92. Epub 2006 Dec 21. PMID:17257835

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal Structure of Human Beta Secretase Complexed with inhibitor'''
+===Crystal Structure of Human Beta Secretase Complexed with inhibitor===
-==Overview==
+<!--
-A series of low-molecular weight 2,6-diamino-isonicotinamide BACE-1 inhibitors containing an amine transition-state isostere were synthesized and shown to be highly potent in both enzymatic and cell-based assays. These inhibitors contain a trans-S,S-methyl cyclopropane P(3) which bind BACE-1 in a 10s-loop down conformation giving rise to highly potent compounds with favorable molecular weight and moderate to high susceptibility to P-glycoprotein (P-gp) efflux.
+The line below this paragraph, {{ABSTRACT_PUBMED_17257835}}, adds the Publication Abstract to the page
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+-->
+{{ABSTRACT_PUBMED_17257835}}
 ==About this Structure==
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 [[Category: Bace]]
 [[Category: Hydrolase]]
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