1ttu: Difference between revisions

Revision as of 14:52, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1ttu.png

Template:STRUCTURE 1ttu

Crystal Structure of CSL bound to DNACrystal Structure of CSL bound to DNA

Template:ABSTRACT PUBMED 15297877

About this StructureAbout this Structure

1TTU is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA., Kovall RA, Hendrickson WA, EMBO J. 2004 Sep 1;23(17):3441-51. Epub 2004 Aug 5. PMID:15297877

Page seeded by OCA on Sun Jul 27 14:52:19 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1ttu.gif|left|200px]]
+{{Seed}}
+[[Image:1ttu.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1ttu|  PDB=1ttu  |  SCENE=  }}
-'''Crystal Structure of CSL bound to DNA'''
+===Crystal Structure of CSL bound to DNA===
-==Overview==
+<!--
-Notch signaling is a conserved pathway of communication between neighboring cells that results in cell fate specification, and CSL is the universal transcriptional effector of Notch signaling. The Notch intracellular domain translocates to the nucleus after proteolytic release upon Notch extracellular engagement, and there it displaces corepressors from DNA-bound CSL and recruits activators of Notch target genes. Here we report the 2.85 A crystal structure of CSL with a target DNA. CSL comprises three structurally integrated domains: its amino (NTD)- and carboxy (CTD)-terminal domains are strikingly similar to those of Rel transcription factors, but a surprising beta-trefoil domain (BTD) is inserted between them. CSL-bound DNA is recognized specifically by conserved residues from NTD and BTD. A hydrophobic pocket on BTD is identified as the likely site of Notch interaction with CSL, which has functional implications for the mechanism of Notch signaling.
+The line below this paragraph, {{ABSTRACT_PUBMED_15297877}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15297877 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15297877}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Rel homology region]]
 [[Category: Transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:21:22 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:52:19 2008''