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| [[Image:2z6h.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2z6h| PDB=2z6h | SCENE= }} | | {{STRUCTURE_2z6h| PDB=2z6h | SCENE= }} |
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| '''Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain'''
| | ===Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain=== |
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| ==Overview==
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| beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix that packs on the C-terminal end of the armadillo repeat domain, and thus forms part of the beta-catenin superhelical core. The existence of this helix redefines our view of interactions of beta-catenin with some of its critical partners, including ICAT and Chibby, which may form extensive interactions with this C-terminal domain alpha helix. Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner.
| | The line below this paragraph, {{ABSTRACT_PUBMED_18334222}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 18334222 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_18334222}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Ubl conjugation]] | | [[Category: Ubl conjugation]] |
| [[Category: Wnt signaling pathway]] | | [[Category: Wnt signaling pathway]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:00:14 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:43:32 2008'' |