2qe5: Difference between revisions

Revision as of 14:31, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2qe5.png

Template:STRUCTURE 2qe5

Structure of HCV NS5B Bound to an Anthranilic Acid InhibitorStructure of HCV NS5B Bound to an Anthranilic Acid Inhibitor

Template:ABSTRACT PUBMED 17402724

About this StructureAbout this Structure

2QE5 is a Single protein structure of sequence from Hepatitis c virus subtype 1b. Full crystallographic information is available from OCA.

ReferenceReference

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase., Nittoli T, Curran K, Insaf S, DiGrandi M, Orlowski M, Chopra R, Agarwal A, Howe AY, Prashad A, Floyd MB, Johnson B, Sutherland A, Wheless K, Feld B, O'Connell J, Mansour TS, Bloom J, J Med Chem. 2007 May 3;50(9):2108-16. Epub 2007 Apr 3. PMID:17402724

Page seeded by OCA on Sun Jul 27 14:31:23 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2qe5.jpg|left|200px]]
+{{Seed}}
+[[Image:2qe5.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2qe5|  PDB=2qe5  |  SCENE=  }}
-'''Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor'''
+===Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor===
-==Overview==
+<!--
-A series of potent anthranilic acid-based inhibitors of the hepatitis C NS5B polymerase has been identified. The inhibitors bind to a site on NS5B between the thumb and palm regions adjacent to the active site as determined by X-ray crystallography of the enzyme-inhibitor complex. Guided by both molecular modeling and traditional SAR, the enzyme activity of the initial hit was improved by approximately 100-fold, yielding a series of potent and selective NS5B inhibitors with IC50 values as low as 10 nM. These compounds were also inhibitors of the HCV replicon in cultured HUH7 cells.
+The line below this paragraph, {{ABSTRACT_PUBMED_17402724}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17402724 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17402724}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Svenson, K.]]
 [[Category: Transferase polymerase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:47:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:31:23 2008''