2ghm: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2ghm.gif|left|200px]]
+{{Seed}}
+[[Image:2ghm.png|left|200px]]
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 {{STRUCTURE_2ghm|  PDB=2ghm  |  SCENE=  }}
-'''Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449'''
+===Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449===
-==Overview==
+<!--
-A new class of tumor necrosis factor alpha (TNF-alpha) synthesis inhibitors based on an N-2,4-pyrimidine-N-phenyl-N'-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar activity against lipopolysaccharide stimulated TNF-alpha production. X-ray co-crystallization studies with mutated p38alpha showed that these trisubstituted ureas interact with the ATP-binding pocket in a pseudo-bicyclic conformation brought about by the presence of an intramolecular hydrogen bonding interaction.
+The line below this paragraph, {{ABSTRACT_PUBMED_16632356}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16632356 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16632356}}
 ==About this Structure==
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 [[Category: Walter, R L.]]
 [[Category: Map kinase p38]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:07:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:25:07 2008''