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| [[Image:2b1h.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2b1h| PDB=2b1h | SCENE= }} | | {{STRUCTURE_2b1h| PDB=2b1h | SCENE= }} |
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| '''Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG29 peptide'''
| | ===Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG29 peptide=== |
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| ==Overview==
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| Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human immunodeficiency virus type 1-infected individual. 2219 was originally selected for binding to a V3 fusion protein and can neutralize primary isolates from subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3 antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily contacting conserved residues on the N-terminal beta-strand of V3, leaving the V3 crown or tip largely accessible. Three V3/2219 complexes reveal the antibody-bound conformations for both the N- and C-terminal regions that flank the V3 crown and illustrate how twisting of the V3 loop alters the relative dispositions and pairing of the amino acids in the adjacent V3 beta-strands and how the antibody can accommodate V3 loops with different sequences.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16731948}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16731948 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16731948}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Hiv-1]] | | [[Category: Hiv-1]] |
| [[Category: V3 loop]] | | [[Category: V3 loop]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:44:06 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:38:43 2008'' |