2fxk: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2fxk.gif|left|200px]]
+{{Seed}}
+[[Image:2fxk.png|left|200px]]
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 {{STRUCTURE_2fxk|  PDB=2fxk  |  SCENE=  }}
-'''Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)'''
+===Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)===
-==Overview==
+<!--
-Histone macroH2A is a hallmark of mammalian heterochromatin. Here we show that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose (OAADPR) through its macro domain. The 1.6-A crystal structure and mutants reveal how the metabolite is recognized. Mutually exclusive exon use in the gene H2AFY produces macroH2A1.2, whose tissue distribution differs. MacroH2A1.2 shows only subtle structural changes but cannot bind nucleotides. Alternative splicing may thus regulate the binding of nicotinamide adenine dinucleotide (NAD) metabolites to chromatin.
+The line below this paragraph, {{ABSTRACT_PUBMED_15965484}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15965484 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15965484}}
 ==About this Structure==
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 [[Category: Macro-domain]]
 [[Category: P-loop]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:25:24 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:05:34 2008''