2bj9: Difference between revisions

Revision as of 12:35, 27 July 2008

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File:2bj9.png

Template:STRUCTURE 2bj9

NIKR WITH BOUND NICKEL AND PHOSPHATENIKR WITH BOUND NICKEL AND PHOSPHATE

Template:ABSTRACT PUBMED 15826657

About this StructureAbout this Structure

2BJ9 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

ReferenceReference

Structure of Pyrococcus horikoshii NikR: nickel sensing and implications for the regulation of DNA recognition., Chivers PT, Tahirov TH, J Mol Biol. 2005 May 6;348(3):597-607. PMID:15826657

Page seeded by OCA on Sun Jul 27 12:35:01 2008

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OCA

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-'''NIKR WITH BOUND NICKEL AND PHOSPHATE'''
+===NIKR WITH BOUND NICKEL AND PHOSPHATE===
-==Overview==
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-The Pyrococcus horikoshii OT3 genome contains a gene (PH0601 or nikR) encoding a protein (PhNikR) that shares 33.8% amino acid sequence identity with Escherichia coli nickel responsive repressor NikR (EcNikR), including many residues that are functionally important in the E.coli ortholog. We succeeded in crystallization and structural characterization of PhNikR in the apo form and two nickel bound forms that exhibit different conformations, open and closed. Moreover, we have identified a putative "low-affinity" nickel-binding pocket in the closed form. This binding site has unusual nickel coordination and exhibits high sensitivity to phosphate in the crystal structure. Analysis of the PhNikR structures and structure-based mutational studies with EcNikR reveals a plausible mechanism of nickel-dependent promoter recognition by the NikR family of proteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_15826657}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_15826657}}
 ==About this Structure==
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