1njg: Difference between revisions

Revision as of 12:29, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1njg.png

Template:STRUCTURE 1njg

Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma SubunitNucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit

Template:ABSTRACT PUBMED 12623013

About this StructureAbout this Structure

1NJG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit., Podobnik M, Weitze TF, O'Donnell M, Kuriyan J, Structure. 2003 Mar;11(3):253-63. PMID:12623013

Page seeded by OCA on Sun Jul 27 12:29:04 2008

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OCA

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-'''Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit'''
+===Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit===
-==Overview==
+<!--
-Sliding clamps are loaded onto DNA by ATP-driven clamp loader complexes. The structure of the E. coli clamp loader in a nucleotide-free state has been determined previously. We now report crystal structures of a truncated form of the isolated gamma-ATPase subunit, gamma(1-243), of the E. coli clamp loader, in nucleotide-free and bound forms. The gamma subunit adopts a defined conformation when empty, in which the nucleotide binding site is blocked. The binding of either ATPgammaS or ADP, which are shown to bind with equal affinity to gamma(1-243), induces a change in the relative orientation of the two domains such that nucleotides can be accommodated. This change would break one of the gamma:gamma interfaces seen in the empty clamp loader complex, and may represent one step in the activation process.
+The line below this paragraph, {{ABSTRACT_PUBMED_12623013}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12623013 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12623013}}
 ==About this Structure==
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 [[Category: Sensor 1]]
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-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:36:21 2008''
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