2rjs: Difference between revisions

Revision as of 10:05, 23 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2rjs.png

Template:STRUCTURE 2rjs

SgTAM bound to substrate mimicSgTAM bound to substrate mimic

Template:ABSTRACT PUBMED 18078753

About this StructureAbout this Structure

2RJS is a Single protein structure of sequence from Streptomyces globisporus. Full crystallographic information is available from OCA.

ReferenceReference

Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM., Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD, Bioorg Med Chem Lett. 2007 Nov 19;. PMID:18078753

Page seeded by OCA on Wed Jul 23 10:05:30 2008

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OCA

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-==Overview==
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-The synthesis and evaluation of two classes of inhibitors for SgTAM, a 4-methylideneimidazole-5-one (MIO) containing tyrosine aminomutase, are described. A mechanism-based strategy was used to design analogs that mimic the substrate or product of the reaction and form covalent interactions with the enzyme through the MIO prosthetic group. The analogs were characterized by measuring inhibition constants and X-ray crystallographic structural analysis of the co-complexes bound to the aminomutase, SgTAM.
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 [[Category: Isomerase]]
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