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| [[Image:1u9b.gif|left|200px]] | | {{Seed}} |
| | [[Image:1u9b.png|left|200px]] |
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| {{STRUCTURE_1u9b| PDB=1u9b | SCENE= }} | | {{STRUCTURE_1u9b| PDB=1u9b | SCENE= }} |
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| '''MURINE/HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9'''
| | ===MURINE/HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9=== |
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| ==Overview==
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| Murine/human ubiquitin-conjugating enzyme Ubc9 is a functional homolog of Saccharomyces cerevisiae Ubc9 that is essential for the viability of yeast cells with a specific role in the G2-M transition of the cell cycle. The structure of recombinant mammalian Ubc9 has been determined from two crystal forms at 2.0 A resolution. Like Arabidopsis thaliana Ubc1 and S. cerevisiae Ubc4, murine/human Ubc9 was crystallized as a monomer, suggesting that previously reported hetero- and homo-interactions among Ubcs may be relatively weak or indirect. Compared with the known crystal structures of Ubc1 and Ubc4, which regulate different cellular processes, Ubc9 has a 5-residue insertion that forms a very exposed tight beta-hairpin and a 2-residue insertion that forms a bulge in a loop close to the active site. Mammalian Ubc9 also possesses a distinct electrostatic potential distribution that may provide possible clues to its remarkable ability to interact with other proteins. The 2-residue insertion and other sequence and structural heterogeneity observed at the catalytic site suggest that different Ubcs may utilize catalytic mechanisms of varying efficiency and substrate specificity.
| | The line below this paragraph, {{ABSTRACT_PUBMED_9261152}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9261152 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9261152}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Ubiquitin-conjugating enzyme]] | | [[Category: Ubiquitin-conjugating enzyme]] |
| [[Category: Ubiquitin-directed proteolysis]] | | [[Category: Ubiquitin-directed proteolysis]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:55:31 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:51:40 2008'' |