1t1b: Difference between revisions

Revision as of 12:33, 10 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1t1b.png

Template:STRUCTURE 1t1b

Late intermediate IL2 from time-resolved crystallography of the E46Q mutant of PYPLate intermediate IL2 from time-resolved crystallography of the E46Q mutant of PYP

Template:ABSTRACT PUBMED 15642261

About this StructureAbout this Structure

1T1B is a Single protein structure of sequence from Halorhodospira halophila. Full crystallographic information is available from OCA.

ReferenceReference

A structural pathway for signaling in the E46Q mutant of photoactive yellow protein., Rajagopal S, Anderson S, Srajer V, Schmidt M, Pahl R, Moffat K, Structure. 2005 Jan;13(1):55-63. PMID:15642261

Page seeded by OCA on Thu Jul 10 12:33:13 2008

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OCA

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-'''Late intermediate IL2 from time-resolved crystallography of the E46Q mutant of PYP'''
+===Late intermediate IL2 from time-resolved crystallography of the E46Q mutant of PYP===
-==Overview==
+<!--
-In the bacterial photoreceptor photoactive yellow protein (PYP), absorption of blue light by its chromophore leads to a conformational change in the protein associated with differential signaling activity, as it executes a reversible photocycle. Time-resolved Laue crystallography allows structural snapshots (as short as 150 ps) of high crystallographic resolution (approximately 1.6 A) to be taken of a protein as it functions. Here, we analyze by singular value decomposition a comprehensive time-resolved crystallographic data set of the E46Q mutant of PYP throughout the photocycle spanning 10 ns-100 ms. We identify and refine the structures of five distinct intermediates and provide a plausible chemical kinetic mechanism for their inter conversion. A clear structural progression is visible in these intermediates, in which a signal generated at the chromophore propagates through a distinct structural pathway of conserved residues and results in structural changes near the N terminus, over 20 A distant from the chromophore.
+The line below this paragraph, {{ABSTRACT_PUBMED_15642261}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15642261 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15642261}}
 ==About this Structure==
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 [[Category: Pas domain]]
 [[Category: Photoactive yellow protein]]
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