1mq8: Difference between revisions

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-[[Image:1mq8.jpg|left|200px]]
+{{Seed}}
+[[Image:1mq8.png|left|200px]]
 <!--
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 {{STRUCTURE_1mq8|  PDB=1mq8  |  SCENE=  }}
-'''Crystal structure of alphaL I domain in complex with ICAM-1'''
+===Crystal structure of alphaL I domain in complex with ICAM-1===
-==Overview==
+<!--
-The structure of the I domain of integrin alpha L beta 2 bound to the Ig superfamily ligand ICAM-1 reveals the open ligand binding conformation and the first example of an integrin-IgSF interface. The I domain Mg2+ directly coordinates Glu-34 of ICAM-1, and a dramatic swing of I domain residue Glu-241 enables a critical salt bridge. Liganded and unliganded structures for both high- and intermediate-affinity mutant I domains reveal that ligand binding can induce conformational change in the alpha L I domain and that allosteric signals can convert the closed conformation to intermediate or open conformations without ligand binding. Pulling down on the C-terminal alpha 7 helix with introduced disulfide bonds ratchets the beta 6-alpha 7 loop into three different positions in the closed, intermediate, and open conformations, with a progressive increase in affinity.
+The line below this paragraph, {{ABSTRACT_PUBMED_12526797}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12526797 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12526797}}
 ==About this Structure==
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 [[Category: Metal mediated protein interface]]
 [[Category: Rossmann fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:35:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 00:51:41 2008''