1mpv: Difference between revisions

Revision as of 00:45, 3 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1mpv.png

Template:STRUCTURE 1mpv

Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptideStructure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide

Template:ABSTRACT PUBMED 12387744

About this StructureAbout this Structure

1MPV is a Single protein structure. Full experimental information is available from OCA.

ReferenceReference

BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2., Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM, Immunity. 2002 Oct;17(4):515-24. PMID:12387744

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1mpv.gif|left|200px]]
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 {{STRUCTURE_1mpv|  PDB=1mpv  |  SCENE=  }}
-'''Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide'''
+===Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide===
-==Overview==
+<!--
-The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52. NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells. Furthermore, wild-type mice injected with BAFF-neutralizing BR3-Fc protein showed reduced basal NF-kappaB2 activation. BR3-Fc treatment of NZB/WF1 mice, which develop a fatal lupus-like syndrome, inhibited NF-kappaB2 processing and attenuated the disease process. Since inhibiting the BR3-BAFF interaction has therapeutic ramifications, the ligand binding interface of BR3 was investigated and found to reside within a 26 residue core domain. When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF.
+The line below this paragraph, {{ABSTRACT_PUBMED_12387744}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12387744 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12387744}}
 ==About this Structure==
-MPV is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA].
+MPV is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA].
 ==Reference==
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 [[Category: Yin, J.]]
 [[Category: Beta-hairpin]]
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