1mp8: Difference between revisions

Revision as of 00:40, 3 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1mp8.png

Template:STRUCTURE 1mp8

Crystal structure of Focal Adhesion Kinase (FAK)Crystal structure of Focal Adhesion Kinase (FAK)

Template:ABSTRACT PUBMED 12467573

About this StructureAbout this Structure

1MP8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography., Nowakowski J, Cronin CN, McRee DE, Knuth MW, Nelson CG, Pavletich NP, Rogers J, Sang BC, Scheibe DN, Swanson RV, Thompson DA, Structure. 2002 Dec;10(12):1659-67. PMID:12467573

Page seeded by OCA on Thu Jul 3 00:40:06 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal structure of Focal Adhesion Kinase (FAK)'''
+===Crystal structure of Focal Adhesion Kinase (FAK)===
-==Overview==
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-Protein kinases are important drug targets in human cancers, inflammation, and metabolic diseases. This report presents the structures of kinase domains for three cancer-associated protein kinases: ephrin receptor A2 (EphA2), focal adhesion kinase (FAK), and Aurora-A. The expression profiles of EphA2, FAK, and Aurora-A in carcinomas suggest that inhibitors of these kinases may have inherent potential as therapeutic agents. The structures were determined from crystals grown in nanovolume droplets, which produced high-resolution diffraction data at 1.7, 1.9, and 2.3 A for FAK, Aurora-A, and EphA2, respectively. The FAK and Aurora-A structures are the first determined within two unique subfamilies of human kinases, and all three structures provide new insights into kinase regulation and the design of selective inhibitors.
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+{{ABSTRACT_PUBMED_12467573}}
 ==About this Structure==
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 [[Category: Thompson, D A.]]
 [[Category: Tyrosine protein kinase]]
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