1m6f: Difference between revisions

Revision as of 23:18, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1m6f.png

Template:STRUCTURE 1m6f

Strong Binding in the DNA Minor Groove by an Aromatic Diamidine With a Shape That Does Not Match the Curvature of the GrooveStrong Binding in the DNA Minor Groove by an Aromatic Diamidine With a Shape That Does Not Match the Curvature of the Groove

Template:ABSTRACT PUBMED 12431090

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove., Nguyen B, Lee MP, Hamelberg D, Joubert A, Bailly C, Brun R, Neidle S, Wilson WD, J Am Chem Soc. 2002 Nov 20;124(46):13680-1. PMID:12431090

Page seeded by OCA on Wed Jul 2 23:18:55 2008

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-'''Strong Binding in the DNA Minor Groove by an Aromatic Diamidine With a Shape That Does Not Match the Curvature of the Groove'''
+===Strong Binding in the DNA Minor Groove by an Aromatic Diamidine With a Shape That Does Not Match the Curvature of the Groove===
-==Overview==
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-A combination of biophysical techniques has been used to characterize the interaction of an antitrypanosomal agent, CGP 40215A, with DNA. The results from a broad array of methods (DNase I footprinting, surface plasmon resonance, X-ray crystallography, and molecular dynamics) indicate that this compound binds to the minor groove of AT DNA sequences. Despite its unusual linear shape that is not complementary to that of the DNA groove, a high binding affinity was observed in comparison with other similar but more curved diamidine compounds. The amidine groups at both ends of the ligand and the -NH groups on the linker are involved in extensive and dynamic H-bonds to the DNA bases. Complementary and consistent results were obtained from both the X-ray and molecular dynamics studies; both of these methods reveal direct and water-mediated H-bonds between the ligand and the DNA.
+The line below this paragraph, {{ABSTRACT_PUBMED_12431090}}, adds the Publication Abstract to the page
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 ==About this Structure==
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 [[Category: Minor groove binder]]
 [[Category: Nucleic acid]]
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