1m60: Difference between revisions

Revision as of 23:17, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1m60.png

Template:STRUCTURE 1m60

Solution Structure of Zinc-substituted cytochrome cSolution Structure of Zinc-substituted cytochrome c

Template:ABSTRACT PUBMED 12761660

About this StructureAbout this Structure

1M60 is a Single protein structure of sequence from Equus caballus. Full experimental information is available from OCA.

ReferenceReference

Structural analysis of zinc-substituted cytochrome c., Qian C, Yao Y, Tong Y, Wang J, Tang W, J Biol Inorg Chem. 2003 Apr;8(4):394-400. Epub 2002 Dec 14. PMID:12761660

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 {{STRUCTURE_1m60|  PDB=1m60  |  SCENE=  }}
-'''Solution Structure of Zinc-substituted cytochrome c'''
+===Solution Structure of Zinc-substituted cytochrome c===
-==Overview==
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-Zinc-substituted cytochrome c has been widely used in studies of protein-protein interactions and photo-induced electron transfer reactions between proteins. However, the coordination geometry of zinc in zinc-substituted cyt c has not yet been determined; two different opinions about the coordination have been reached. Here the solution structures of zinc-substituted cytochrome c that might be five-coordinated and six-coordinated have been refined separately by using (1)H NMR spectroscopy, and the zinc coordination geometry was determined just by NOE distance constraints. Structural analysis of the energy-minimized average solution structures of both the pentacoordinated and hexacoordinated geometries indicate that that zinc in zinc-substituted cyt c should be bound to both His18 and Met80, which means that the zinc is six-coordinated. RMSD values of the family of 25 six-coordinated structures from the average structure are 0.66+/-0.13 A and 1.09+/-0.16 A for the backbone and all heavy atoms, respectively. A statistical analysis of the structure indicates its satisfactory quality. Comparison of the solution structure of the six-coordinated energy-minimized average structure of zinc-substituted cytochrome c with the solution structure of reduced cytochrome c reveals that for the overall folding the secondary structure elements are very close. The availability of the structure provides for a better understanding of the protein-protein complex and for electron transfer processes between Zn cyt c and other metalloproteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_12761660}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_12761660}}
 ==About this Structure==
-M60 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M60 OCA].
+M60 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M60 OCA].
 ==Reference==
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 [[Category: Yao, Y.]]
 [[Category: Six-coordinated zinc cyt c]]
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