1m4q: Difference between revisions

Revision as of 23:12, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1m4q.png

Template:STRUCTURE 1m4q

STRUCTURE OF THE TSG101 UEV DOMAIN IN COMPLEX WITH A HIV-1 PTAP "LATE DOMAIN" PEPTIDE, CNS ENSEMBLESTRUCTURE OF THE TSG101 UEV DOMAIN IN COMPLEX WITH A HIV-1 PTAP "LATE DOMAIN" PEPTIDE, CNS ENSEMBLE

Template:ABSTRACT PUBMED 12379843

About this StructureAbout this Structure

1M4Q is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1. Full experimental information is available from OCA.

ReferenceReference

Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein., Pornillos O, Alam SL, Davis DR, Sundquist WI, Nat Struct Biol. 2002 Nov;9(11):812-7. PMID:12379843

Page seeded by OCA on Wed Jul 2 23:12:13 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1m4q.jpg|left|200px]]
+{{Seed}}
+[[Image:1m4q.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1m4q|  PDB=1m4q  |  SCENE=  }}
-'''STRUCTURE OF THE TSG101 UEV DOMAIN IN COMPLEX WITH A HIV-1 PTAP "LATE DOMAIN" PEPTIDE, CNS ENSEMBLE'''
+===STRUCTURE OF THE TSG101 UEV DOMAIN IN COMPLEX WITH A HIV-1 PTAP "LATE DOMAIN" PEPTIDE, CNS ENSEMBLE===
-==Overview==
+<!--
-The structural proteins of HIV and Ebola display PTAP peptide motifs (termed 'late domains') that recruit the human protein Tsg101 to facilitate virus budding. Here we present the solution structure of the UEV (ubiquitin E2 variant) binding domain of Tsg101 in complex with a PTAP peptide that spans the late domain of HIV-1 p6(Gag). The UEV domain of Tsg101 resembles E2 ubiquitin-conjugating enzymes, and the PTAP peptide binds in a bifurcated groove above the vestigial enzyme active site. Each PTAP residue makes important contacts, and the Ala 9-Pro 10 dipeptide binds in a deep pocket of the UEV domain that resembles the X-Pro binding pockets of SH3 and WW domains. The structure reveals the molecular basis of HIV PTAP late domain function and represents an attractive starting point for the design of novel inhibitors of virus budding.
+The line below this paragraph, {{ABSTRACT_PUBMED_12379843}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12379843 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12379843}}
 ==About this Structure==
-M4Q is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4Q OCA].
+M4Q is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4Q OCA].
 ==Reference==
@@ Line 31: / Line 35: @@
 [[Category: Vacuolar protein sorting]]
 [[Category: Virus budding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:37:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 23:12:13 2008''