1m4h: Difference between revisions

Revision as of 23:11, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1m4h.png

Template:STRUCTURE 1m4h

Crystal Structure of Beta-secretase complexed with Inhibitor OM00-3Crystal Structure of Beta-secretase complexed with Inhibitor OM00-3

Template:ABSTRACT PUBMED 12206667

About this StructureAbout this Structure

1M4H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3., Hong L, Turner RT 3rd, Koelsch G, Shin D, Ghosh AK, Tang J, Biochemistry. 2002 Sep 10;41(36):10963-7. PMID:12206667

Page seeded by OCA on Wed Jul 2 23:11:25 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1m4h.gif|left|200px]]
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 {{STRUCTURE_1m4h|  PDB=1m4h  |  SCENE=  }}
-'''Crystal Structure of Beta-secretase complexed with Inhibitor OM00-3'''
+===Crystal Structure of Beta-secretase complexed with Inhibitor OM00-3===
-==Overview==
+<!--
-The structure of the catalytic domain of human memapsin 2 bound to an inhibitor OM00-3 (Glu-Leu-Asp-LeuAla-Val-Glu-Phe, K(i) = 0.3 nM, the asterisk denotes the hydroxyethylene transition-state isostere) has been determined at 2.1 A resolution. Uniquely defined in the structure are the locations of S(3)' and S(4)' subsites, which were not identified in the previous structure of memapsin 2 in complex with the inhibitor OM99-2 (Glu-Val-Asn-LeuAla-Ala-Glu-Phe, K(i) = 1 nM). Different binding modes for the P(2) and P(4) side chains are also observed. These new structural elements are useful for the design of new inhibitors. The structural and kinetic data indicate that the replacement of the P(2)' alanine in OM99-2 with a valine in OM00-3 stabilizes the binding of P(3)' and P(4)'.
+The line below this paragraph, {{ABSTRACT_PUBMED_12206667}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12206667 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_12206667}}
 ==About this Structure==
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 [[Category: Beta-secretase]]
 [[Category: Memapsin2]]
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