1m3h: Difference between revisions

Revision as of 23:08, 2 July 2008

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File:1m3h.png

Template:STRUCTURE 1m3h

Crystal Structure of Hogg1 D268E Mutant with Product OligonucleotideCrystal Structure of Hogg1 D268E Mutant with Product Oligonucleotide

Template:ABSTRACT PUBMED 15610848

About this StructureAbout this Structure

1M3H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structures of end products resulting from lesion processing by a DNA glycosylase/lyase., Chung SJ, Verdine GL, Chem Biol. 2004 Dec;11(12):1643-9. PMID:15610848

Page seeded by OCA on Wed Jul 2 23:08:18 2008

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OCA

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-'''Crystal Structure of Hogg1 D268E Mutant with Product Oligonucleotide'''
+===Crystal Structure of Hogg1 D268E Mutant with Product Oligonucleotide===
-==Overview==
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-DNA glycosylase/lyases initiate the repair of damaged nucleobases in the genome by catalyzing excision of aberrant nucleobases and nicking of the lesion-containing DNA strand. Nearly all of these proteins have the unusual property of remaining tightly bound in vitro to the end products of the reaction cascade. We have taken advantage of this property to crystallize and structurally characterize the end product resulting from complete DNA processing by a catalytically active mutant form of human 8-oxoguanine DNA glycosylase (D268E hOgg1). The resulting structure is consistent with the currently accepted catalytic mechanism for the protein. Unexpectedly, however, soaking of a nucleobase analog into the crystals results in religation of the DNA backbone in situ.
+The line below this paragraph, {{ABSTRACT_PUBMED_15610848}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15610848 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_15610848}}
 ==About this Structure==
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 [[Category: Mutant]]
 [[Category: Protein-dna complex]]
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