|
|
| Line 1: |
Line 1: |
| [[Image:1m2z.gif|left|200px]] | | {{Seed}} |
| | [[Image:1m2z.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_1m2z| PDB=1m2z | SCENE= }} | | {{STRUCTURE_1m2z| PDB=1m2z | SCENE= }} |
|
| |
|
| '''Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif'''
| | ===Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment. Here, we report the crystal structure of the human GR ligand binding domain (LBD) bound to dexamethasone and a coactivator motif derived from the transcriptional intermediary factor 2. Despite structural similarity to other steroid receptors, the GR LBD adopts a surprising dimer configuration involving formation of an intermolecular beta sheet. Functional studies demonstrate that the novel dimer interface is important for GR-mediated activation. The structure also reveals an additional charge clamp that determines the binding selectivity of a coactivator and a distinct ligand binding pocket that explains its selectivity for endogenous steroid hormones. These results establish a framework for understanding the roles of protein-hormone and protein-protein interactions in GR signaling pathways.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12151000}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12151000 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_12151000}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 43: |
Line 47: |
| [[Category: Hormone binding pocket]] | | [[Category: Hormone binding pocket]] |
| [[Category: Tif2]] | | [[Category: Tif2]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:34:06 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:06:24 2008'' |