1lwc: Difference between revisions

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-[[Image:1lwc.jpg|left|200px]]
+{{Seed}}
+[[Image:1lwc.png|left|200px]]
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 {{STRUCTURE_1lwc|  PDB=1lwc  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE'''
+===CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE===
-==Overview==
+<!--
-Six structures of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) containing combinations of resistance mutations for zidovudine (AZT) (M41L and T215Y) or lamivudine (M184V) have been determined as inhibitor complexes. Minimal conformational changes in the polymerase or nonnucleoside RT inhibitor sites compared to the mutant RTMC (D67N, K70R, T215F, and K219N) are observed, indicating that such changes may occur only with certain combinations of mutations. Model building M41L and T215Y into HIV-1 RT-DNA and docking in ATP that is utilized in the pyrophosphorolysis reaction for AZT resistance indicates that some conformational rearrangement appears necessary in RT for ATP to interact simultaneously with the M41L and T215Y mutations.
+The line below this paragraph, {{ABSTRACT_PUBMED_12208978}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12208978 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12208978}}
 ==About this Structure==
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 [[Category: Nevirapine]]
 [[Category: Nrti]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:21:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 22:38:55 2008''